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Prof John Isaacs, who has worked on the condition for 35 years and is leading the research, believes this could make it possible to "switch off" rheumatoid arthritis.

Prominent 18th-Century scientists, including Sir Isaac Newton, thought that navigation with marine clocks was impossible.

Then there was the three by Canyon’s Isaac Yuhico with 21 seconds left in the first overtime to tie the score.

And Isaac’s lack of an appropriate neck accessory made him the laughingstock of a dinner party at John Jay’s house the night they were meant to sign the Declaration of Independence.

As Mr Isaacs tried to avoid being stabbed he came into contact with Ms Maximen, who fell to the ground, the jury was told.