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Ashley Ann Kuzma died on Sept. 22 after being diagnosed with laryngeal cancer and undergoing chemotherapy, 29 radiation treatments and a laryngectomy to remove her voice box — all over the last two years.

Others had had laryngectomies, or else defective hearing, or learning disabilities, or for an unknown reason had begun speaking much later than was normal.

It is the agency's first national anti-smoking advertising effort and features people whose smoking resulted in heart surgery, laryngectomy, lost limbs or paralysis.

The CDC said Monday that the hole in Wright's throat resulted from a laryngectomy - the removal of his voice box - not a tracheotomy.

The health department has also used media campaigns, including graphic antismoking advertisements, like a 1997 television commercial that showed a woman smoking a cigarette through the laryngectomy hole in her throat.