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Among the most important are Aristotle’s classification of causes into material, formal, efficient and final, set forth in his Physics and elsewhere, and known as his doctrine of the Four Causes; Geulincx’s Occasional Causes, meant as a solution of certain difficulties in the cosmology of Descartes; Leibnitz’s law of Sufficient Reason; and Kant’s explanation of cause and effect as an a priori category of the understanding, intended as an answer to Hume’s scepticism, but very much less effective than the line of explanation suggested by Locke.