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A discovery by Simona Stäger's team could help come up with a treatment to the most serious form of leishmaniasis.

The most serious form of the disease, known as visceral leishmaniasis, is invariably fatal within 2-years if untreated.

In its effort to hunt for new treatments for leishmaniasis, the program has partnered with the Drugs for Neglected Diseases Initiative, or DNDi, a nonprofit research and development organization based in Geneva.

Researchers analyzed leishmaniasis lesions on mouse skin to detect metabolic signaling pathways that differed from uninfected mice.

“While most of these infections were in people living in Texas, sand flies that can transmit leishmaniasis are found in many parts of the country and especially in the southern United States,” Kamb said.