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A recent study from the Powell lab at Yale University has since confirmed that some of the offspring of the GM mosquitoes didn’t succumb to the self-limiting lethal gene and survived to adulthood.

Oxitec’s latest strain of GM mosquitoes is designed to spread the lethal gene more effectively.

Despite the enormous potential for such efforts to yield drug targets, a challenge remains: how can researchers systematically search for synthetically lethal gene relationships?

When I ask him the probability of his three sons inheriting the same lethal gene, there's a pause and he chokes up.

Identification of essential genes and synthetic lethal gene combinations in Escherichia coli K-12.