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But subsequent analyses show this variant is not necessary or sufficient to extend life span.

The Mediterranean island, they thought, offered ideal conditions for studying the genes and habits that can influence life span: Its population is relatively isolated, with low rates of immigration and little genetic diversity.

When Pes and his colleagues first visited Sardinia in the 1990s, they had speculated that the secret to the population’s longevity could be in their DNA—rare gene variants associated with an extended life span.

"The chance of a flood occurring at least once in an 80-year lifetime is 55% for a 1-in-100-year flood and 15% for a 1-in-500-year flood. The likelihood of experiencing such devasting floods over a life span is much higher than people might think."

"One of the things that we know about addictive disorders is that people often will continue to consume the substance despite it causing consequences for them," said Michael Amlung, associate director for training at the Cofrin Logan Center at the KU Life Span Institute.