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The new framework offers a straightforward way to calculate the lower bounds on the energy cost of those situations.

Most important, bariatric surgery seems to reset, to a lower bound, the body weight that the brain tries to maintain.

“The threshold we looked at in this paper I would think of as the lower bound,” Powis said.

Even so, the system only gives the county a concrete lower bound.

But because the lower bound of the confidence interval around this figure fell below FDA’s required 20%, it didn’t meet the agency’s efficacy standard for preventing less severe disease.