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macrolide
/ ³¾Äƒ°ì′°ùÉ™-±ôÄ«»å′ /
- Any of a class of organic compounds containing a large lactone ring made up of twelve or more members.
- Any of a class of antibiotics having a macrolide ring structure linked to one or more sugars. Macrolides are produced by actinomycete bacteria of the genus Streptomyces and act by inhibiting protein synthesis. Erythromycin is a macrolide.
Example Sentences
“We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for the treatment of COVID-19,†the study reported.
"Today, three of the authors of the paper, 'Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis', have retracted their study," the editors of The Lancet said in a statement Thursday.
The original study in The Lancet, which was published on May 22, purported to find that when either hydroxychloroquine or its relative drug chloroquine is used either alone or with a macrolide, there was no benefit in terms of treating COVID-19.
“Today, three of the authors have retracted ‘Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis’,†tweeted the Lancet on Thursday.
"The use of hydroxychloroquine or chloroquine in COVID-19 is based on widespread publicity of small, uncontrolled studies, which suggested that the combination of hydroxychloroquine with the macrolide azithromycin was successful in clearing viral replication," the authors of the study wrote.
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