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The team then created transgenic flies with the four missense variants found in affected individuals using two different genetic methods.

The tool's predictions for missense variants across the entire genome are accessible for non-commercial use and analysis at https://itanlab.shinyapps.io/goflof/.

Brain metastases of smokers versus non-smokers had different missense mutations in TP53 and EGFR, except for L858R and T790M in EGFR, which were seen in both subgroups.

Among the cohort, 46 patients had missense variants of the gene U2AF2 and six patients had variants of the gene PRPF19.

Deeper profiling revealed that at third gene, RBFOX1, had missense variants that affected splicing and loss of proper neuron function.