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But the experience of many close observers leads to caution in anticipation of necessary and permanent disability of the heart because of murmurs, or even functional disturbances, seeming to prove either aortic or mitral insufficiency or stenosis.

Another case was that of a woman who "was suffering from compensatory enlargement of the heart from mitral insufficiency," was taken with dyspnœa when Dr. Jennings was called and was nearly dead.

This arteriosclerotic endocarditis at times leads to very definite heart lesions, chiefly aortic or mitral insufficiency, or both with, at times, murmurs of a stenotic character at the base.

Mitral insufficiency may show an exceedingly low picture or an exceedingly high picture.

A number of affections are accompanied by œdema, especially toward the latter stages of the disease; such, for instance, as the ending of cases of mitral insufficiency.