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Dr. Griffiths, a distinguished psychopharmacologist and professor at the Johns Hopkins School of Medicine in Baltimore, spent decades studying the mechanisms of dependence on mood-altering drugs.

Processed foods might provoke compulsive behaviors that reinforce the need to consume more, but do they really have mood-altering effects, another criterion used to define an addiction?

The fact that Americans are overprescribed mood-altering drugs and are addicted to social media and other technology contributes to this denial and disengagement with reality.

In his opening essay, Dr. Gaylin wrote that despite the promise of mood-altering drugs to understand mental illness, addiction and other health problems, they aroused as much discomfort as they did satisfaction.

With opioid abuse wreaking havoc on the country, we were finally going to get to the root of the nation’s deadly obsession with mood-altering drugs.