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Gaynor remembered him as humble and almost classically nerdy, happy to spend hours on the phone explaining how motor neurons work.

Testing in a mouse model of the disease showed that 4-PBA significantly improved motor function, extended lifespan, and increased the number of healthy motor neurons.

AFM attacks motor neurons in the spinal cord’s gray matter, which controls movement.

While the present study examined "upper" motor neurons in the brain, Heiman and Kellis are now seeking to also characterize connected "lower" motor neurons in the spinal cord, also in collaboration with Belzil.

Despite this pivotal duty, researchers are only now beginning to uncover the role that single motor neurons play in movement.