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Colin Carlson, a biologist at Georgetown University, has started to worry about mousepox.

One of the more famous examples is how the introduction of an extra gene in mousepox – the mouse version of smallpox – made it far more lethal and able to infect vaccinated individuals.

By adding a single gene to its DNA, Australian researchers turned a mousepox virus that normally causes only mild symptoms in rodents into a virulent killer that wiped out all their lab mice in less than 10 days.