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A firm enlargement of the surface of the face and upper part of the body occurs in myxoedema.

It is found, however, that its removal entails myxoedema, a condition closely allied to cretinism.

But in that year Dr George Murray published his discovery of the effect of hypodermic injections of thyroid gland extract in cases of myxoedema.

He also did valuable work on the internal secretion of organs, the results of which have been applied with the most satisfactory results in the treatment of myxoedema.

But from this time on no further work was undertaken until the discovery of the treatment of myxoedema by thyroid extract, and the consequent researches into the physiology of the ductless glands.