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Its signatories included the actors Joaquin Phoenix, Hari Nef and Debra Winger; the directors Joel Coen, Nicole Holofcener and Boots Riley; the playwright and screenwriter Tom Stoppard; and the artist Nan Goldin, according to Variety, which reported the existence of the letter on Friday.

Nef’s casting is an answer of sorts to the controversy of cis actors playing trans characters.

In fact, a Candy biopic has long been in the works, and it’s now finally in the filming stage, starring trans actress Hari Nef.

One key to HIV's ability to remain hidden in patients' cells is a protein that the virus makes, called Nef.

Synthetic chemists in the lab then created more than 70 new variations of the compound, swapping out different chemical groups, to test for their potency against HIV Nef.