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"Even though the results are promising, we need to carry out more studies on larger populations to confirm our findings and to determine the long-term effects of nicotinamide riboside in treatment for COPD," Morten Scheibye-Knudsen explains.

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

"This is a signal that nicotinamide riboside could help these patients," said Christiaan Leeuwenburgh, Ph.D., a UF professor of physiology and aging and senior author of the clinical trial report.

The scientists recruited 90 people with an average age of 71 who had peripheral artery disease, or PAD, to test the effects of nicotinamide riboside.

Nicotinamide riboside is a precursor for the essential compound NAD, which plays roles in the body related to energy generation, improved blood flow and DNA repair.