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Many painkiller options already exist, with opioids remaining the most effective drugs in most cases where severe acute, nociceptive pain is concerned — that aching, throbbing pain encompassing everything from bruises to arthritis to broken bones.

Cutting nociceptive nerves, though, generally backfires because, as we have noted, nerve injury can promote the onset of even more stubborn, persistent pain.

The distinctions between pain types are not clean: If left untreated, nociceptive pain may sensitize the nervous system, turning a temporary problem into chronic, nociplastic pain, for example.

Upon receiving a nociceptive pain message, the brain’s pain regulation network can either inhibit or enhance the pain experience according to the context.

Nav1.7 channels are found nearly exclusively in peripheral nociceptive neurons in the dorsal root ganglia; these nerve centres in the spinal column are the first ‘relay station’ in transmitting pain-related information to the brain.