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Within months of the 1986 Chernobyl meltdown, in the former Soviet Union, approximately 30 operators and firefighters on-site died of acute radiation syndrome, but investigators nearly two decades later found “no scientific evidence of increases in overall cancer incidence or mortality or in non-malignant disorders that could be related to radiation exposure.”

This drug also became widely used for chronic, non-malignant pain.

It would be interesting to see whether the same machine-learning approach could use Nam and colleagues’ gene-expression data to distinguish the malignant cells from non-malignant cells.

However, only around 36% of non-malignant brain tumours occurred in men, compared with 64% in women, during the same period in the United States1.

Purdue also kept an eye on methadone, noting in a 1999 marketing plan that “market research as well as reports from the sales force indicates that methadone use is increasing in both the management of cancer pain and non-malignant pain due to its low cost.”