�y��vlog

The paper — titled “In silico screening for potential COVID-19 beta-coronavirus non-nucleoside RdRp inhibitors” — was posted on the website of “Prospero Pharmaceuticals,” which identifies itself as a biotech company that’s “developing therapies for unmet medical needs in orphan diseases.”

Bristol early next year plans to begin Phase III testing of an all-oral, three-drug combination that adds BMS791325 - a non-nucleoside polymerase inhibitor - to the two drugs tested in the Japanese study.

Drug resistance was serious only in eastern and southern Africa, and mostly involved a class of medications called non-nucleoside reverse transcriptase inhibitors.

They show that non-nucleoside reverse transcriptase inhibitors and protease inhibitors exhibit cooperative dose-response curves—a finding that has implications for the treatment of HIV as well as other viral infections, such as hepatitis C.