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Both norethindrone and norethynodrel provided synthetic counterparts of progesterone that overcame that limitation.

A few months later, the team synthesized a hormone known as norethindrone.

He developed a synthetic molecule called norethindrone, the effects of which simulated, in stronger form, those of progesterone.

But women using estrogen with norethindrone or desogesterel at certain doses, for example, had double the risk of both complications compared to non-users.