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It is also a potent oncogene, meaning the very growth it promotes in skeletal muscle could stimulate cellular proliferation if overexpressed in organs like the liver, resulting in tumors.

Houlahan and Curtis decided to focus on oncogenes, normal genes that, when mutated, can free a cell from regulatory pathways meant to keep it on the straight and narrow.

He expressed optimism by saying, "Given ETV4's substantial implications as a critical oncogene, we envision leveraging this insight to devise technologies aimed at controlling cancer cells through mechanical cues."

Having shown that quelling the fused oncogene killed tumor cells, they decided to experiment with derailing kinase A activity, which research indicated was driving tumor growth.

TRABI-Seq is being tested on various cancer cells to determine trabectedin's efficacy in targeting tumors with advanced DNA repair capabilities, often associated with elevated transcription levels due to oncogene activation.