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"Our new catalytic system can generate Fischer-carbene complexes from organosilicon compounds, which are non-toxic," explains Tetsuya Inagaki, lead author of the study.

The researchers improved the efficiency of their biocatalyst by directed evolution — sequentially inducing mutations in the enzyme's active site and screening for improved activity — and say it could lead to new classes of pharmaceuticals and industrial catalysts using organosilicon molecules.