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“While the ortho-toluidine exposure levels in the plant have generally been far below the permissible exposure limits, engineering controls were put in place in the 1980s to further reduce levels in the plant,” the company said.

Ortho-toluidine is in a family of chemicals—aromatic amines—known since the 1930s to cause bladder cancer, Wodka said.

Rats also developed bladder tumors after they ingested ortho-toluidine.

The list of known carcinogens now includes a chemical called ortho-toluidine, which is used to make rubber chemicals, pesticides and dyes.

But HHS scientists re-evaluated the substance, looking at three studies of dye workers and two studies of rubber-chemical workers who were regularly exposed to ortho-toluidine.