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Barr-Gillespie suggests a deeper knowledge of the transduction process might also prove helpful with hearing loss acquired from exposure to noise or ototoxic drugs—about half of the 460 million cases worldwide.

In all, there are more than 200 known ototoxic medications on the market today, according to the American-Speech-Language-Hearing Association, which can also impact the ear's balance functions.​

Oricula Therapeutics – Developing medications to protect hearing and balance from the effects of aging and ototoxic drugs, or medications that are toxic to the ear.

Disruption of the sensory hair bundle by genetic mutation, loud sounds, or ototoxic drugs can lead to hair-cell dysfunction and deafness. 

The resulting expression stimulated regeneration of spiral ganglion neurites, which had atrophied 2 weeks after ototoxic treatment, in a bilateral sensorineural deafness model.