�y��vlog

Several years ago, scientists studying aging at the Harvard Stem Cell Institute used a somewhat Frankensteinian technique known as parabiosis — surgically joining a young mouse and an old mouse so that they share blood — to see what would happen to the heart and skeletal muscle tissue.

It was co-founded in 2018 by Amy Wagers, who was on the Stanford parabiosis revival team and is now a professor of stem-cell and regenerative biology at Harvard University.

Which approach is likely to best slow or reverse age-related diseases based on parabiosis’s effects?

Ambrosia’s approach irks many scientists trying to methodically translate the effects of parabiosis into therapies to slow or reverse ageing.

Studies published in 2013 and 2014 by Wagers’s laboratory and those of the company’s other scientific co-founders, showed that old mice injected with GDF11 reproduced several of the parabiosis findings – with regeneration seen in the heart, skeletal muscle and brain.