�y��vlog

Progressive supranuclear palsy is a form of atypical parkinsonian syndrome, also known as a Parkinson-plus disorder, according to the National Institutes of Health.

What’s more, the rats developed parkinsonian symptoms: unsteady movements and hunched postures, shaking paws and severe rigidity.

Like rotenone, paraquat causes rodents to develop parkinsonian symptoms and pathology, and other researchers have used it to make animal models of the disease.

Atypical Parkinsonian disorders have some signs and symptoms of Parkinson’s — muscle stiffness, tremor and problems with walking, balance and fine motor coordination — but do not respond well to treatment with drugs commonly used against Parkinson’s, according to Johns Hopkins Medicine.

Building on this type of work, researchers tested antipsychotic drugs that block dopamine receptors and found the medications improved fluency in some people, although the drugs came with the risk of severe side effects such as parkinsonian movement disorders.