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Introduced by our mutual friends, she was pitched to me as “tall and blond, with curly hair,” a historically winning phenotype for me, even if that “blond” mention was an elaborate brunette farce.

The paper, "Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels," appears in the Journal of Clinical Investigation.

Despite these directional trends, however, ceratioids also displayed remarkable variability in body shapes from the archetypical globose anglerfish to elongated forms like the "wolftrap" phenotype, which features a jaw structure resembling a trap.

"But if this stress stays there, which it does in the tumor microenvironment, the cells are just in continuous stress, and that will then lead to a very different phenotype and death," Mehrotra said.

"Interestingly, we found that this opioid-seeking phenotype occurs significantly more in males compared to females, and we are currently performing research with our colleagues at UMSOM, to determine why this is the case."