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Nasal tanners are designed to be sprayed into the nostrils and claim to work by administering a substance known as Melanotan II, a chemical that darkens skin pigmentation.

Immediately ostracized by the students for her green pigmentation, Elphaba explodes with fury when her sister is abruptly removed from her care.

After consulting her dermatologist, Simpson-Einziger was diagnosed with a temporary fungal infection called Tinea versicolor, which can lighten or darken skin pigmentation as a result of humidity.

One of them, for example, is responsible for the pigmentation of the maggots' teeth, while another is responsible for the formation of the striped pattern on the fly's abdomen.

She has spoken in the past about how she was seen as a "devil's child" in the orphanage because she suffered from vitiligo, a condition in which patches of skin lose pigmentation.