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Chemotherapy and a stem-cell transplant failed to produce a second remission, and in his weakened immune state, he developed a dangerous case of pneumocystis pneumonia.

This is gonna explode into something that we haven’t seen,’” Fauci recalled of his prescient outlook regarding the emerging clusters of gay men suffering often fatal cases of Pneumocystis pneumonia and a rare cancer, Kaposi sarcoma.

It was extremely important — both clinically, in that it alerted doctors to think about Pneumocystis carinii when evaluating pneumonia in men who have sex with men, and scientifically, in that it spurred researchers to investigate why these otherwise healthy men were suddenly dying.

Given the prevalence of pneumocystis pneumonia, smoking marijuana was not a safe option for many people with AIDS.

In the early 1980s, for instance, it was clinicians’ observations that pneumocystis pneumonia co-occurred with Kaposi’s sarcoma in men in San Francisco that led to the identification of HIV/AIDS as the common risk factor19.