�y��vlog

The SARS-CoV-2 spike protein cleaves more readily than equivalent proteins in other coronaviruses, because it has evolved something called a polybasic cleavage site, which Drosten likens to the perforations on a notepad that make it easier to rip off a page.

Interestingly, a polybasic motif proximal to H8 in many GPCRs has been shown to facilitate G-protein pre-coupling and influence the rate of receptor activation.

Indeed, it seems as if he almost anticipated the later doctrines of types and polybasic acids, and in none of his work did he show more discriminating observation or acute reasoning.

In the case of the polybasic acids, all the hydrogen atoms can be replaced in this way, and the compounds formed are known as “neutral esters.”

Further and stronger support was given when J. Liebig promoted his doctrine of polybasic acids.