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It examines how 160 people with the anhedonia depression subtype, who often aren't helped by antidepressant drugs, respond to two treatments: transcranial magnetic stimulation, a noninvasive therapy that uses magnetic fields to stimulate nerve cells and is approved for treatment-resistant depression, and pramipexole, a drug for Parkinson's disease.

Pramipexole mimics dopamine, the signaling molecule for the reward circuit that seems sluggish in those patients.

If Moe's inability to experience pleasure is driven by too little dopamine, pramipexole could help, Williams says.

Using drugs that stimulate dopamine receptors in the brain, such as ropinirole, pramipexole or rotigotine, can help control RLS symptoms.

To identify the brain location involved in these decisions, the researchers gave rats a drug used to treat Parkinson’s disease, pramipexole, marketed as Mirapex, which acts on D2 receptors and seems to dampen some patients’ ability to restrain risk-seeking behavior.