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Uptravi, among a class of drugs called oral IP prostacyclin receptor agonists, relaxes and opens blood vessels, easing the elevated pressure, the agency said.

Trans fats also prevent the synthesis of a lipid called prostacyclin, which causes blood clots.

The most common adverse events associated with selexapig were similar to those seen with previous prostacyclin therapies, including headache, diarrhea, nausea, jaw pain, vomiting, pain in extremity, myalgia, nasopharyngitis and flushing.

The drug, selexipag, is a first-in-class orally available selective prostacyclin IP receptor agonist.

Prostacyclin therapy is used for patients with severe right heart failure and is first line in these patients.