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Instead of needing this whole extraction with special equipment, if we simply treat the saliva with an enzyme called proteinase K and heat it, we can successfully break open the virus.

Enriched chromatin was then subjected to crosslink reversal and proteinase K digestion at 65 °C, phenol–chloroform extraction and ethanol precipitation.

Here, we demonstrate that TLR4 is activated by airway proteinase activity to initiate both allergic airway disease and antifungal immunity.

These outcomes were induced by proteinase cleavage of the clotting protein fibrinogen, yielding fibrinogen cleavage products that acted as TLR4 ligands on airway epithelial cells and macrophages.