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They noticed one protein, called proteoglycan glypican-1, was found in much higher levels in people with pancreatic cancer.

Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.

The results suggest that proteoglycan biosynthesis is tightly regulated by a microRNA pathway to shape the cell surface glycosylation architecture required to direct neuronal migration.

Goblet cells produce mucin, that is organized into a dense, more highly cross-linked inner proteoglycan gel that forms an IEC-adherent inner mucous layer, and a less densely cross-linked outer mucous layer.

Goblet cells produce mucin, that is organized into a dense, more highly cross-linked inner proteoglycan gel that forms an IEC-adherent inner mucous layer, and a less densely cross-linked outer mucous layer.