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Although protein changes related to familial AD increase amyloid-β levels directly, they might also have consequences for processes other than APP proteolysis.

Presumably, the chimaeric protein used in our Letter was unaffected because the conditions did not favour proteolysis.

Further, increase in acidity increases proteolysis, thereby liberating alkaline ammonia-derivatives which tend to neutralize the rising acidity and so to restore normal neutrality or alkalinity.

Excitatory activity promotes the proteolysis of APP and its release into the extracellular space27, 28, 29.