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A new study demonstrates that ketone bodies and similar metabolites have profound effects on the proteome and protein quality control in the brain.

One of the leaders of the analysis, John Prensner, began peering into the dark proteome because so many of his searches among known genes for ones related to cancer turned up empty-handed.

"Then using mass spectrometry, we could increase the depth of proteome coverage by over seven-fold."

The fact that the team found a core insoluble proteome enriched with numerous proteins that had not been considered before creates new targets for exploration, said Lithgow.

The researchers developed a method to interrogate the entire human proteome for 'effector' proteins, which can influence the stability of other proteins via induced proximity.