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Researchers say cancer cells need to run out of pyrimidine building blocks, including uridine nucleotides, before the cells will self-destruct.

Olorofim, the compound Hoenigl is testing, is one example: It blocks the synthesis of pyrimidine, the precursor of DNA building blocks.

Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow.

Therefore, the immediate 3′ and 5′ nucleotides of all somatic SNVs were extracted from the reference genome and the obtained trinucleotides were converted to pyrimidine context resulting in 96 possible mutation types.

Neither phosphorus atoms nor the purine and pyrimidine bases were on hand.