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Lead author Alexia Kirby, who is a doctoral student in biology, was responsible for validating and testing the radiotracer across various cell and animal models, while Nicholas Calvert, a doctoral student in chemistry and biomolecular sciences, used carbon isotope labeling to determine the metabolic pathway of the radiotracer in cells.

A new tau PET radiotracer, 18F-SNFT-1, has been found to be more effective than existing tau PET radiotracers in identifying Alzheimer's disease in its earliest stages, according to research published in the September issue of The Journal of Nuclear Medicine.

Called a SPECT-CT scan, it combines two different types of images: a single-photon emission computed tomography scan, which uses a radiotracer injected into a person’s veins to provide pictures of blood flow, and a standard CT scan for information about lung structure.

For neurodegenerative conditions, the main contenders in the disease biomarker market now are PET imaging using radiotracer ligands that bind to proteins, and analysis of cerebrospinal fluid.

In the 1990s, David Goldstein, a neurocardiologist at the US National Institute of Neurological Disorders and Stroke in Bethesda, Maryland, developed a radiotracer called fluorodopamine to visualize dopamine neurons with a positron emission tomography scan, which led to an unexpected discovery.