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By applying Mendelian randomization, a powerful causal inference method, the researchers identified 33 out of 913 metabolites studied present in the blood that were associated with bipolar disorder, most of them lipids.

The randomization algorithms enables future patients joining the trial to have increased odds of getting the best drug for them personally.

There’s a method in genetics called Mendelian randomization that mimics a randomized controlled trial, so we can test for causal and not correlative associations between different foods and different diseases.

More evidence comes from Mendelian randomization studies, which compare the health of people who carry different gene variants to tease out cause and effect.

However, contrary to our hypothesis, this Mendelian randomization analysis did not show significant effects of gut microbiota on metabolic factors and chronic diseases.