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The Bush order did inspire California to establish the California Institute for Regenerative Medicine in 2004 with a $3-billion bond issue approved by voters.

"Treating patients with epilepsy allows us to investigate the purpose of generating new neurons in our brains. We observe that one of reasons is to learn from the conversations we have" said co-corresponding author Michael Bonaguidi, an associate professor of stem cell biology and regenerative medicine, gerontology, biochemistry and molecular medicine, biomedical engineering, and neurological surgery, and assistant director of the USC Neurorestoration Center.

It further opens the door to developing functional tissues and organs and progress in the field of regenerative medicine, the researchers said.

"This technique is a significant advancement in rapid bioprinting of spheroids," said Ibrahim T. Ozbolat, Dorothy Foehr Huck and J. Lloyd Huck Chair in 3D Bioprinting and Regenerative Medicine and professor of engineering science and mechanics, of biomedical engineering and of neurosurgery at Penn State.

Organoids are three-dimensional cellular constructs that replicate the functions of human organs, attracting significant attention in the fields of human organ development, disease modeling, and regenerative medicine research.