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While I have been able to improvise care for some of them with IV fluids, bloodwork, electrolyte repletions and blood transfusions in the outpatient setting, Ms. H’s acuity was beyond the limits of my clinic.

The story is about painful repletion of another kind, and of solace that never arrives.

With repletion came dissatisfaction: a hunger for something more, or for something different.

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.

Where once the odd coneflower looked dried in the flower beds, other plants follow the same course, until there is a wholesale shift in the character of the garden from repletion to decline and seediness.