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As adenosine accumulates throughout the day, it slows down excitatory networks such as the arousal-causing reticular activating system.

An X-ray of Mr McHugh's lungs taken six weeks after he left hospital showed thin white lines, known as reticular shadowing, that could indicate the early signs of scarring or pulmonary fibrosis.

Also, brain scans show that practicing gratitude can rewire our reticular activating system.

Drew, T. Functional organization within the medullary reticular formation of the intact unanesthetized cat.

From there the neuron doctrine spread, replacing the prevailing reticular theory.