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Catholic saints practiced self-mortification, such as wearing itchy sackcloth, to encourage humility and to create greater compassion for the suffering of others.

Yes, the game can be a tough mistress, the source of frayed nerves, sleepless nights and bottomless self-mortification.

The run-up to Easter is particularly enjoyable because of the intrinsic delayed gratification, and the discomfort of low-grade self-mortification.

“I was involved in an immense self-mortification,” she says.

Ayahuasca isn’t the only time-honored method of ritual self-mortification, of course; pilgrims seeking an encounter with the divine have a long history of fasting, hair shirts, and flagellation.