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There can be “a huge liability issue” if a pregnant study volunteer has a baby with a birth defect, for example, says Marie Teil, a clinical trialist with experience in research ethics.

Teil questions whether experimental treatments, whose effectiveness is by definition unproven, should be offered in pregnancy given unknown risks to the fetus.

But, Teil says, other avenues are available for learning.

Now high on Teil’s todo list is keeping track of those who become pregnant during any UCB drug trial, though she says she does not expect the company would continue them on experimental medications.

Iñárritu’s only stipulation to casting director Manuel Teil was that all had to have theatrical training.