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These conditions may be produced by a primary irritation of the nerve centers of the brain from the effects of heat, as is seen in thermic fever, or sunstroke, or by the entrance into the blood stream of disease-producing organisms or their chemical products, as in anthrax, rinderpest, influenza, etc.

Sunstroke, or thermic fever, is generally believed to be instantaneous in its onset, but the wide experience of the English in India has shown that whilst in some cases it is thus sudden in its development, in others it is a slow process, and probably in almost all cases close observation would have revealed the existence of premonitions.