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However, especially given the similarity between the peat-bog environment and tuberculosis lesions, the findings provide support for a particular strategy for development of treatment-shortening drugs: targeting the biological processes that maintain thiol levels in the tuberculosis bacterium.

However, despite this success, creating o-bromobenzenethiols by adding a bromine molecule and a thiol group to these intermediates has been tough.

The UAB researchers were able to cleave four interchain disulfide bonds in the trastuzumab IgG1 hinge and near hinge regions, creating thiol groups.

The thiol groups of Cys residues are known7 to be a target for oxidation by H2O2.

For HPCA1 to function properly as a receptor for eH2O2, the Cys oxidation process must be readily reversible, re-forming thiol residues that can be oxidized again.