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The company aggressively marketed the drug and its timed-release properties to doctors for use in patients with chronic pain.

The products compounding pharmacies make are not subject to testing, and the timed-release formulation may vary from batch to batch.

Cutting the timed-release pills releases a rush of medication.

Utsunomiya, who has spoken with residents concerned about the particles, is trying to figure out how long it will take for these beads to dissolve in water; their glassy casing means they are likely to break down slowly, their radioactive components leaching out like a timed-release medicine capsule, as Ewing describes it.

But McKerrall and others caution that opioid addicts have devised strategies to defeat other abuse-resistant formulations, for example, by crushing pills that have timed-release coatings.