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The convulsions may come on altogether unexpectedly, but commonly the attack begins with symptoms of toxaemia.

The indication for it was that disease was largely due to a toxaemia or accumulation of poisons in the system, the modern idea of auto-toxaemia, and that these could be best removed by brisk purgation.

This toxaemia affects the marrow and through it the blood, the gastro-intestinal apparatus and the nervous system, especially the spinal cord, in different proportions in different cases.

Nothing that so drives out the littlenesses that poison his life and set up the toxaemia of selfishness.