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Instead of chisels and mallets to open a skull, Cushing carefully drilled holes with a hand trephine, a cousin of the wooden-handle corkscrew.

We aspirated all brain tissue inside the trephine.

Had been trephined in right parietal region before coming under our observation.

With his hands full of chisels, trephines, and mallets Marcy went to cross the room, and chanced to trip on a rug, falling headlong.

The little animal lies on the table insensible, chloroformed, while with the sharp-toothed little trephine the operator makes a tiny hole in its skull, lays bare the brain, and inserts the virus.