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To try and synopsize the various trials and tribulations of the Genovese crime family during the first half of the 20th century would be a fool’s errand, and both Levinson and Pileggi recognize that, focusing on a few key events in the story of the longtime relationship between Costello and Genovese — namely, the latter’s botched hit on the former in 1957 — while glossing over most of their backstory in rapid-fire montage.

Fielding says she finds it "comforting" that women in their 20s have a real interest in Bridget’s trials and tribulations.

"It's been a long journey. You don't just get here. I left home at 14, moved to Jamaica, then Texas. I have been through a lot of trials and tribulations, a lot of hardships," Alfred said.

But who better to navigate the trials and tribulations of the holiday season than your best friend?

Ph.D., and colleagues write in the review, "Trials and tribulations of cell therapy for heart failure: an update on ongoing trials," published in Nature Reviews Cardiology.